Medicham is a humanoid, bipedal Pokémon that resembles a yoga practitioner. It has a gray body with red and yellow adornments. A red headpiece with three bulb-like extensions covers the upper portion of its head: one on top and one on either side. The bulb on top is short on a female Medicham. Its large, focused eyes are slightly covered by the headpiece, and its red lips seem to be in a rounded or puckered position. Its legs appear to be covered with puffy, red pants that have a large yellow spot on the knees and yellow bands next to the hips.
Through the power of meditation and fasting, Medicham has developed a sixth sense. This allows it to use psychokinetic powers, and it heightens its energy to enhance this sixth sense. It battles with elegant, dance-like movements, which it uses to dodge attacks and launch devastating blows. The anime has shown that it can sense aura. It only eats once per month. It lives in fields and mountains. It will hide by using its powers to blend into its surroundings. In Generation IX, Power Trick is its signature move.
As Mega Medicham, its headpiece now resembles a white turban with a yellow stone in the center. The red extension in the back is retained, and there are five white extensions on the turban, three extending from the stone and one on either side of its head. There is now a gold band on each wrist and additional gold bands around its waist. Several blue, teardrop-shaped decorations hang from the lowest hip band. Using its enhanced willpower, Mega Medicham has formed four ghost-like arms around itself. The more trained its spirit, the more realistic and dexterous its self-created arms become.
Like its pre-evolved form Meditite, Medicham is one of the few Pokémon whose official art depicts the female form.
In Generation III, before the introduction of gender differences, all Meditite and Medicham had the appearance of a female regardless of gender.
Medicham's normal and Shiny colorations are opposites of those of its pre-evolution Meditite. Medicham's normal coloration is mainly pink, while its Shiny coloration is mainly blue, whereas Meditite is blue and pink, respectively.
Medicham resembles a primate of some sort, like its pre-evolved form. It appears to have been based on a practitioner of yoga. It may have also been based on Arabian belly dancers, as its pants resemble traditional badlah pants and its headgear resembles a shawl. One headpiece growth, the longest one, resembles a ponytail, which can be seen on Persian genies in most American fiction, such as Jeannie of I Dream of Jeannie, who also wear bedlahs.