Scolipede is a centipede-like Pokémon that usually stands with the front half of its body raised vertically off the ground. Its segmented body is dark magenta, except for its smooth, dark gray underside. Long, slightly bent horns similar to antennae extend from its head, as well as an identical pair of horns on its rear. Purple bands decorate these horns, and teardrop-shaped rings of the same color mark each body segment, one on each side of its body. It possesses four pairs of short, purple fore-claws on the body segments that make up its neck, which is used to inject poison. The four hind legs are longer, thicker, and spaced farther apart. Each hind limb has curved dark gray bands around the middle.
Scolipede lives in lush forests. It is very aggressive and will not give up until victorious. This Pokémon chases down enemies with great speed and then attacks relentlessly with its horns until it prevails. It latches onto the prey with the claw's toxic spikes and then slams it into the ground for the deadly poison effect. Centiskorch is the natural predator or prey of Scolipede, depending on who wins the territorial fight.
Despite the Scolipede and Centiskorch evolutionary families living in different parts of the Galarregion, both Venipede and Scolipede's Pokédex entries speak of their hostile relationship with the latter family.