Salazzle is a dark gray Pokémon resembling a salamander or lizard. Its thin body has a purple underside with several wavy, dark pink markings: a U-shaped marking with two additional lines inside on its chest and one on each hip resembling wisps of smoke. The dark gray on its head and neck extends slightly onto its chest in a V-shape. It has a slender head with purple, almond-shaped eyes with slit pupils and two fang-like projections on each side of its lower jaw. There are two thin, wavy growths on its back at the base of its tail, which is whip-like with a dark pink underside. Its hands and feet each have five long, thin digits. Salazzle is a female-only species with no known male counterpart.
Salazzle can be found deep in caves with a reverse harem of male Salandit. The males are attracted by the pheromones in the poisonous gas created by Salazzle. The males bring it food, and those that are unable to are punished with flaming slaps. Salazzle's gas can also be diluted to make perfumes.
Salazzle and its pre-evolution are also the only Poison-type Pokémon with a double resistance to Fairy-type moves.
Salazzle appears to be based on a salamander and lizards of the Teiidae family, also known as "whiptails". Certain whiptail species have a mostly female population, some species even being female exclusive, one of which is the New Mexico whiptail. It may also be partially based on fire belly newts.
Additionally, it may be inspired by the mo'o, a mythical dragon-like lizard of Hawaiian myth. Generally, mo'o are depicted as large female lizards, which have scales that are black as night, and which would shape-shift into seductive women to devour men. They would also appear when fire was lit near or around their dwellings.
Salazzle may be a combination of salamander and dazzle or sizzle.
Ennewt may be a combination of 炎 en (flame) or 艶 en (bewitching) and newt.