The Safari Zone is a special Pokémon preserve where Trainers can enter to catch certain types of Pokémon. It is owned by the Warden.
For 500, the player will receive 30 Safari Balls. With a large area to cover, Trainers must plan out their destination so as to arrive in time to capture all the Pokémon they want.
When a wild Pokémon appears, no Pokémon may be sent out to battle it: catching Pokémon here, as in all Safari Zones, requires sheer luck. There are four options in the battle screen: throw a Safari Ball, throw Bait, throw a Rock, and run away. Throwing Bait makes a Pokémon less likely to run, but makes it harder to catch; while throwing a Rock does the reverse, making it easier to catch but more likely to run.
Safari Zone Warden Baoba is the man in charge of the Kanto Safari Zone. His house is located on the southeastern side of the city. He lives in a cottage next to the Pokémon Center. The locals of Fuchsia nicknamed the Warden "Slowpoke" because he has a vacant look similar to that seen on a Slowpoke. He's actually very knowledgeable about Pokémon, which should only be natural as taking care of the Safari Zone Pokémon is part of his job. He has a collection of rare Pokémon Fossils. He has recently lost his false teeth in the Safari Zone and has become unable to speak clearly. If the player character of the Kanto Generation I or Generation III games returns his teeth to him, he'll give them HM04 (Strength). Wild Pokémon appear in the city in a pond behind the Warden's house.
He also runs a promotion in the Safari Zone. Pokémon Trainers who find the Secret House on the grounds are given HM03 (Surf). It's probable that he's friends with Koga, as the Gym Leader patrols the grounds of the Safari Zone to keep things safe. Koga's daughter, Janine, also trains just outside of the Safari Zone.
In Generation II, the Warden has left on a trip, so the Safari Zone has been shut down and most of the exclusive Pokémon have been moved to adjacent Routes. In HeartGold and SoulSilver, however, the park's closing led to the opening of a Pal Park. It's also in these games that the Warden's name is revealed to be Baoba. Wishing to maintain the Safari Game, Baoba opens another Safari Zone in Johto.
In Generation III, a Move Deleter resides in a house in Fuchsia City that cannot be accessed in GenerationsI, II, or IV, next to the city's Pokémon Center. The Move Deleter is a very forgetful man who lives alone. For no charge, he will make a Pokémon forget a move that it knows, provided that the move is not the only move which that Pokémon knows. He is the only way for a Pokémon to forget HM moves such as Cut or Fly.
Three years from Generation I and III to Generation II and IV, the city has changed quite dramatically. The Pokémon Zoo has closed down, transforming the northern half of the city into a grassy plain, only accessible by the use of Cut. There is also a small area in the northwestern part of the city, that contains a Burnt Berry.
In Generation II, Warden Slowpoke has left on a trip, so the Safari Zone has been shut down and most of the exclusive Pokémon have been moved to adjacent routes. In Generation IV, the Safari Zone is replaced with Pal Park instead, with a replacement Safari Zone now found in Johto.
Fuchsia City itself made its proper debut in Time Warp Heals All Wounds, where it was depicted as a deserted, dark-looking place. When her Squirtle wandered off, May chased it to an abandoned railway station. There she discovered an old woman named Edna, who told her that she was waiting for her husband, Jonathan, to return, even though the trains didn't use the station anymore and she had once received a letter to her inform her that Jonathan had died in an accident.
From Edna's granddaughter Katrina, May heard that Edna and Jonathan had once operated a Pokémon breeding Center in Fuchsia City, until Jonathan had suggested that they leave for a while so he could study to become a doctor. Edna, however, had been unwilling to leave her hometown, so Jonathan left for the train station by himself, leaving behind a letter telling of his decision. After reading the letter, Edna had rushed to the station, intending to convince Jonathan to stay, for she, unbeknownst by Jonathan, was carrying a child. Unfortunately, she bumped into a Gentleman on the way, preventing her from reaching Jonathan in time. Even though she got a letter a year later telling of Jonathan's death, she still came to the station every day to wait for his return, refusing to believe that her husband was gone.
Afterwards, May, Squirtle, and Meowth found the pendant Edna had lost back when Jonathan had left. Suddenly the pendant started to glow, and May, Squirtle, and Meowth soon found themselves in the past, back at the day when Jonathan had left Edna. Not wanting the lovers to lose each other, May used her Squirtle's Ice Beam to change the falling rain into a snowfall, delaying the train's departure long enough for Edna to reach Jonathan in time and convince him to stay. Just then, the pendant started to glow again, and May, Squirtle, and Meowth were returned to the present, where their actions in the past had had dramatic results: Fuchsia City was no longer deserted and dark, but lively and full of light, with even the train station still being in use. Just then, Ash, Brock, and Max arrived, telling May that her Egg was about to hatch. When she went with the others to see her Egg at the Pokémon Center, she was surprised to see Edna, Jonathan, and Katrina, who were now working together as Pokémon pediatricians. Due to the past having been changed, neither Edna or Katrina remembered May. Due to May, Squirtle, and Meowth being the only ones having traveled through time, they were the only ones aware of the alternate present.
Later at that night, after May's Egg hatched into an Eevee, Ash, his friends, Edna, Jonathan, and Katrina witnessed the "Lights of Joy", where Volbeat and Illumise danced around a tree in the middle of the city, something that the alternate present had lacked.
Fuchsia City did not appear in the anime until Time Warp Heals All Wounds in the Battle Frontier saga, despite the Gym appearing in the original series, making it the only Kanto settlement to not appear during the original series.