One of the Pewter City's main attractions is the famous museum located in the northwestern part of the city. The main building is open to the public for 50 and features several scientific artifacts.
There are two floors to explore in the Pewter Museum of Science. The first floor holds the front desk and a fossil exhibit containing the fossils of Aerodactyl and Kabutops. The second floor hosts a space exhibit, featuring a space shuttle and a large Moon Stone that fell from space and landed on Mt. Moon. The player is able to explore the museum at any time, after paying the admission fee.
Other known members include Camper Jerry, Camper Liam, Brock's father, Flint, and Brock's mother, Lola.
Pewter Gym appears in all games set in the Kanto region, appearing much the same in each: a small building with a Japanese rock garden inside, one Trainer, and the Gym Leader Brock waiting on a large stone pedestal. In the Generation I games and their Generation III remakes, whenever the player tries to leave Pewter City, a boy will lead them to the front of the Gym if the player has not earned their Boulder Badge yet.
In the Generation I games and their remakes, there's a notice about thieves that have been stealing Pokémon fossils from Mt. Moon and to contact Pewter Police with any information to assist them in stopping the troublemakers.
Pewter City first appeared in Showdown in Pewter City, where Ash decided to challenge the Pewter Gym for his first Badge. After suffering his first loss to Brock, Flint caught up with Ash and directed him to an old hydroelectric plant located by a dry river bed, where he could charge Pikachu up with electricity. After charging Pikachu up, Ash returned to the Gym, where Pikachu accidentally set off its sprinkler system, allowing it to win the rematch against Onix. Despite this, Ash decided to forfeit the match, feeling like he did not deserve to win. Nevertheless, Brock still chose to give him a Boulder Badge. The Gym was subsequently left under Flint's care while Brock decided to join Ash on his travels.
Pewter City made an appearance in File 1: Red. While visiting the Museum of Science, Red overheard two girls talking about Brock, the local Gym Leader. When he went to the Gym, he found out that Brock was the same man whom he had encountered earlier, just after losing a battle against Blue.
Red then started a Gym battle with Brock, during which the Rock-type Gym Leader gave the beginner Trainer basic advices of strategy, such as those involving type effectiveness. During the battle, Red came to realize that he and his Pokémon were in the battle together, making them his partners. Eventually, Red was able to defeat Brock, earning the Boulder Badge and TM34 (Bide). Afterwards, the young Trainer departed Pewter City, doubly determined to fulfill his quest of completing the Pokédex.
Pewter City first appeared Wanted: Pikachu!. After arriving there, Red learned that the townspeople were trying to catch a Pikachu, which had been stealing food from the local marketplace. Using his Bulbasaur's Sleep Powder, Red put Pikachu asleep and caught him without issue. Pikachu did, however, remain disobedient towards him, something that Red's rival, Blue, mocked him for. He also told Red that he was intending on battling the local Gym Leader, Brock, in order to earn the Boulder Badge and make his Pokémon stronger, and challenged Red to do the same. However, the local Pokémon Center had been attacked the previous night, leaving Red's only good choices against Rock Pokémon, Bulbasaur and Poliwhirl, low on HP.
In Onix Is On!, Red entered the Pewter Gym just in time to witness Blue winning himself a Boulder Badge. Red used Bulbasaur and Poliwhirl to face and defeat the GymTrainers, but by the time the battle against Brock came, both of them were too exhausted to continue, forcing Red to use his disobedient Pikachu against Brock's Onix. Despite the obedience issues and type disadvantage, Pikachu eventually defeated Onix by breaking its body apart, earning Red his own Boulder Badge.
Starting from Karate Machop!, a group of Machop sent by Bruno attacked Pewter City as part of the Elite Four's attack on the Kantoregion. While Brock fought against them to defend his hometown, he discovered that the Elite Four was after his Badge. Once Yellow defeated Lance on Cerise Island, the Pokémon armies attacking Kanto lost their strength and collapsed.
Pewter City appeared in Bring Down the Powerful Opponent Onix!!. After seeing Green getting tossed out of the local Gym, Clefairy became afraid of fighting against Brock's Onix and tried to flee, forcing Red to drag him back inside. Once Clefairy found out that his cousin, Pikachu, was a part of Brock's Pokémon collection, he was infuriated and finally became motivated to battle. Onix was eventually defeated by Clefairy's gag moves, making Red the winner and allowing him to take Pikachu with him.
Pewter City appeared in Pewter City, where Satoshi challenged Brock at the Pewter Gym. Despite Brock's Onix having an advantage over Satoshi's Charmander, Satoshi eventually won by having Charmander chop off Onix's horn, earning him the Boulder Badge.
Goldenrod City and Rustboro City are very similar to Pewter City. Their geographic locations in their respective regions are remarkably similar, as well as being only accessible through a forest early in the game. Rustboro is, however, the most like Pewter in that both cities are the second city visited with a Gym, but first to be beat by the player. Both Pewter and Rustboro's Gyms specialize in Rock-typePokémon, and play a role in the player obtaining Fossil Pokémon.
Oreburgh City is also very similar to Pewter City, as they are both surrounded by mountains, both of their Gyms specialize in Rock-typePokémon, and they both contain a museum. Nacrene City is also similar, as it is near a forest and has a museum; however, unlike Pewter City, Goldenrod City and Rustboro City, Nacrene City comes before a forest, not after.
In Pokémon Yellow, if Pikachu is asleep because of Jigglypuff's song, the player will be unable to use the Link Cable features. In this case, the Link Cable attendant simply says her original preparation message: "Welcome to the Cable Club! We're making preparations. Please wait."