Shady House is the base of Team Skull, a dilapidated mansion at the far end of Po Town, where Guzma also stays from time to time.
As the Pokémon Center, like the rest of Po Town, is occupied by Team Skull, no operational Poké Mart, Pokémon Center Café, or PC can be found there. A Team Skull Grunt will, however, offer to heal the player's Pokémon for 10 whenever she's asked to. After the player has become Champion, the Grunt, along with her cohort, will offer to sell them a Skull Tank and Team Skull CapUSUM. If the player purchases the clothing, the two Grunts will leave the Pokémon Center, leaving it with no more functional use.
Po Town debuted in the Sun, Moon, Ultra Sun & Ultra Moon chapter. Gladion traveled there after being made a Team Skull Enforcer by Guzma. Shortly after arriving, Gladion was attacked by Plumeria and a group of Team Skull Grunts, who wanted to see if he was skilled enough for the job. Though Gladion proved himself during the battle, his negative attitude angered Plumeria to the point where she refused to accept him as a true member of Team Skull. When Plumeria told Gladion to follow her, Gladion complied, but was momentarily distracted when a ZygardeCore jumped past him.
Later, Ilima, Lana, Kiawe, Mallow, Acerola, and Hau arrived in Po Town to have a talk with Team Skull. Guzma, appearing on the Shady House's balcony, seemed amused by the suggestion, and accepted the offer to talk, if the group could get into the house first. At that moment, the Trial Captains and Hau found themselves surrounded by a group of Ultra Beasts.
The three beasts proceeded to easily best their opponents, but when Guzma noticed that the Captains' Pokémon were still hanging on, he revealed a Cosmog and had it open more Ultra Wormholes to summon more beasts. The group was saved by Gladion, who used his Type: Null to fight the Ultra Beasts, which it did with ease due to its status as a Pokémon specifically created to fight them. Afterward, Guzma was kidnapped by a Nihilego, which dragged him into an Ultra Wormhole with it. The other beasts then broke out of Po Town's barrier, proceeding to cause havoc on the rest of Ula'ula.
This is the only city or town in Alola where the background music doesn't change depending on the time of day.