Paniola Ranch is made up of fenced-in pastures meant for tending farmland Pokémon such as Tauros and Miltank. A single pathway runs from Paniola Town through a maze of tall grass and ramps to a three-way junction that diverges into the north and south, leading to Routes 5 and 6 respectively.
The Pokémon Nursery is located near the junction at the eastern end of the ranch. Similar to the Pokémon Day Cares found in other regions, the player may leave two Pokémon in the Nursery to produce Pokémon Eggs. Unlike the Day Cares, however, Pokémon that are left here will not level up, and the cost for retrieving a Pokémon is always 500.
Paniola Ranch first appeared in Young Kiawe Had a Farm!, where it was revealed to belong to Kiawe's family. It was also revealed that Kiawe delivers Moomoo Milk products the ranch produces for people across Alola with his Charizard, sometimes even before coming to the Pokémon School in the morning. Ash visited the ranch, helping Kiawe and his family in their farm chores.
In The Ol' Raise and Switch!, Kiawe took Lana's Popplio to his ranch as part of a school project, where his class temporarily traded their partners. Although Kiawe at first had trouble figuring out what to do with Popplio, it eventually proved its usefulness by calming down a pair of fighting Tauros and then helping him wash them.
The ranch reappeared in Big Sky, Small Fry!, where Kiawe visited it with Mallow, Sophocles, and Lillie, who wanted to try out its various Moomoo Milk products, including cheese and ice cream, during their class's stay at Akala Island.
The ranch appeared again in The Young Flame Strikes Back!, when a businessman named Viren attempted to buy the ranch from Kiawe and his family to construct his own resort hotel, but was declined. He then commanded his henchmen to harass the family until they were stopped and arrested by Officer Jenny for forging land owner documents, trespassing, and malicious destruction to property (both legal and private).
The ranch appeared again in Heart of Fire! Heart of Stone!, when Ash and his classmates took Brock and Misty to visit Akala Island. A wild Kangaskhan unexpectedly appeared at the barn, eating the ranch Pokémon's food and acting hostile towards everyone. It turned out that Kangaskhan was protecting her injured child, but Brock was able to calm her down and treat the child's injury, making Kangaskhan peacefully leave the ranch.