Paniola Ranch consists of multiple areas separated by fences and ramps. These areas include Moomoo Paddock, a fenced-in pasture for tending farmland Pokémon, such as Tauros and Miltank. (While several of these Pokémon can be seen in this area, they can only be encountered in the wild in other parts of Paniola Ranch. However, the player can obtain Stoutland as a ride Pokémon here, enabling them to use Stoutland Search.) Moomoo Paddock sits in the western part of Paniola Ranch and can be accessed from the dirt road that connects to Paniola Town in the south. A small pond with a waterfall sits along the western edge of Paniola Ranch within Moomoo Paddock.
The western dirt road also connects to a maze-like area of brown tall grass and earthen ramps in the middle of Paniola Ranch's southern edge. Fences and hay bales create barriers throughout this area, forcing the player to navigate through the grass and over the southernmost ramp to cross from one side of Paniola Ranch to the other. The eastern part of this maze area opens onto the Pokémon Nursery and a small, fenced area containing hay bales and farm equipment.
East of the Pokémon Nursery lies a junction with another dirt road. Following that road to the north leads to Route 5, and following it to the south leads to Route 6. Along the fence running up the northern dirt road, between the hay bales and the windmill, is a Poké Finder spot, where different Pokémon appear depending on the game and time of day.
The Pokémon Nursery is located near the junction at the eastern end of the ranch. Similar to the Pokémon Day Cares found in other regions, the player may leave two Pokémon in the Nursery to produce Pokémon Eggs. Unlike the Day Cares, however, Pokémon that are left here will not level up, and the cost for retrieving a Pokémon is always 500.
Paniola Ranch first appeared in Young Kiawe Had a Farm!, where it was revealed to belong to Kiawe's family. It was also revealed that Kiawe delivers Moomoo Milk products the ranch produces for people across Alola with his Charizard, sometimes even before coming to the Pokémon School in the morning. Ash visited the ranch, helping Kiawe and his family in their farm chores.
In The Ol' Raise and Switch!, Kiawe took Lana's Popplio to his ranch as part of a school project, where his class temporarily traded their partners. Although Kiawe at first had trouble figuring out what to do with Popplio, it eventually proved its usefulness by calming down a pair of fighting Tauros and then helping him wash them.
In Big Sky, Small Fry!, Kiawe visited it with Mallow, Sophocles, and Lillie, who wanted to try out its various Moomoo Milk products, including cheese and ice cream, during their class's stay at Akala Island.
In The Young Flame Strikes Back!, a businessman named Viren attempted to buy the ranch from Kiawe and his family to construct his own resort hotel, but was declined. He then commanded his henchmen to harass the family until they were stopped and arrested by Officer Jenny for forging land owner documents, trespassing, and malicious destruction to property (both legal and private).
In Heart of Fire! Heart of Stone!, Ash and his classmates took Brock and Misty to visit Akala Island. A wild Kangaskhan unexpectedly appeared at the barn, eating the ranch Pokémon's food and acting hostile towards everyone. It turned out that Kangaskhan was protecting her injured child, but Brock was able to calm her down and treat the child's injury, making Kangaskhan peacefully leave the ranch.