The whole route is covered in snow, meaning that it is impossible to ride a bicycle. In some places, the snow is so deep that it cannot be run through, and as a result of the snow, there is constant hail in every battle.
A Warm Bed and Little Else
There is a house named Snowbound Lodge near the western end of the route where Trainers may sleep, healing their party.
Trainers with a Vs. Seeker by their names, when alerted for a rematch using the item, may use higher-level Pokémon.
In the manga
Route 216 in Pokémon Adventures
Snowbound Lodge in Pokémon Adventures
In the Pokémon Adventures manga
Route 216 appeared in Disagreeable Graveler and Striking Out Snover, where Platinum was seen traveling through the route on her way to Lake Acuity. While skiing through the snow, she accidentally hit a wild Graveler, angering it and causing it to break her skiing equipment. Although she was able to get away, her light clothing in the cold weather caused her to fall unconscious in the snow. Thankfully, she was rescued by a girl with an Abomasnow and brought to recover at the Snowbound Lodge, where she both received appropriate winter clothes and learned that the girl who had rescued her was the Snowpoint CityGym LeaderCandice. Upon leaving the Lodge, Platinum encountered Maylene, who was also en route to Snowpoint City, and joined her.