Mr. Mime is a bipedal, humanoid Pokémon. Blue growths resembling clown hair extend from the sides of its pale pink head, and there is a magenta circle on each cheek. Its jaw is curved inward, resembling the mouth of a wooden dummy. It has a round, white body with a magenta spot in the middle, light pink arms and legs that connect to its body via magenta spheres, and small white coverings over its knees. Its white hands resemble gloves with magenta pads on the tips of its white fingers and its dark blue feet curl upward at the tips.
From birth, this Pokémon is an excellent pantomime. As it matures, it gains the ability to solidify air molecules by vibrating its fingertips. This ability allows it to create invisible objects with its gestures. It punishes those who interrupt its act or are not impressed by slapping them. Mr. Mime is usually very rare, but can be found in suburban areas. In Generation II, Substitute was its signature move.
Galarian Mr. Mime are mostly blue and white. It also has blue growths resembling clown hair on its pale head; however, these also extend and cover its cheeks, creating a mutton chop style sideburn effect resembling earmuffs. It has wider-shaped eyes and a small blue triangle for a nose. It has a suit-like body comprising a white top, blue shoulder spheres, blue bottom trousers, and a diamond-shaped crystal that resembles a tie. It has mitten-like hands and feet that are more defined, resembling blue shoes with light blue soles, presumably made out of ice. Through its feet, it is able to control the temperature and create a floor of ice, which it can kick up to act as a barrier. It is widely known in the region for its talent in tap dancing (contrasting Kantonian Mr. Mime's talent in pantomiming) and is likely the result of Mr. Rime's influence over Mime Jr. imitating their dance steps.
In It's Mr. Mime Time, Stella used a Mr. Mime in her circus. However, it was lazy and stopped obeying her because she was too hard on it. It eventually listened to her once more when it saw how much she was willing to protect it from Team Rocket.
In Stage Fight!, a Mr. Mime was part of a showboat stage show.
In Hail to the Chef, a Mr. Mime is the sous-chef of Rhonda. She was competing with her sister Rhoda and her Sneasel for the ownership of her father's restaurant outside of Saffron City. Mr. Mime's cooking was not good, but improved under Brock's tutelage.
Valerie owns a Mr. Mime in PS577, where it was used to help stop the Ultimate weapon from activating. Bryony's familiarity with the tactic used by Valerie's Mr. Mime, by means of referring to pages from an encyclopedia, is a direct reference to the two occasions the tactic was previously used in Pokémon Adventures.
A Mr. Mime appeared in Detective Pikachu, where it was encountered by Detective Pikachu and Tim Goodman at Ryme Wharf while they were searching for the source of the R substance. Having previously been interrogated by Tim's father Harry and Detective Pikachu before, it tried to mime an escape but was unsuccessful. Tim and Pikachu then tried interrogating it, but it taunted them and used Barrier to shield itself from any other questioning. This prompted Tim to try and "get inside its head", and he mimed opening the door to Mr. Mime's "room", pouring gasoline on it, and threatening it by miming a lit match. Mr. Mime relented and revealed that it had gotten the R from the "roundhouse", an illegal fight club owned by Sebastian. In their excitement, Tim accidentally dropped the "match", much to Mr. Mime's horror.
Pokémon Stadium 2: Mr. Mime stars in its own minigame called "Barrier Ball." Poké Balls appear on the field and by using Mr. Mime's Barrier, send the Poké Balls to the other player's fields.
Despite its English name containing a male-exclusive honorific, Mr. Mime's gender ratio is evenly split between male and female.
This discrepancy is probably due to the fact that Mr. Mime's Japanese name, Barrierd, does not reference gender. Also, Mr. Mime was introduced in Generation I, before the gender mechanic was introduced.
Based on his memory, translator Nob Ogasawara was wary about Mr. Mime's English name during localization: "If they make sequels and they give genders to Pokemon [sic], we're going to be hooped."
Galarian Mr. Mime shares its category with Oricorio. They are both known as the Dancing Pokémon.
Mr. Mime and Lycanroc are the only two Pokémon known to have 6 possible Abilities between their forms, the most of any Pokémon.
Mr. Mime seems to be based on a mime artist, specifically the pantomime of pretending to be trapped in invisible boxes. Its brightly colored body is also reminiscent of a clown and a court jester. The blue growths on its head resemble a fool's cap, and its curled feet resemble a jester's hook-toed shoes. Its jerky animations cause it to resemble a jointed puppet or doll. In Japanese folklore, inanimate objects that are possessed by spirits and come to life are known as tsukumogami.
Galarian Mr. Mime appears to be based on both tap dancers and ice skaters. The soles of its feet resemble tap shoes, the blue spots on the sides of its head resemble earmuffs, its conjoined fingers resemble mittens, and the ice on its chest resembles a necktie. Its round body is also reminiscent of a snowman.
Mr. Mime may be derived form the abbreviation of Mister and mime.
Barrierd may be a combination of barrier (referring to the invisible walls it can create) and weird.