001 may refer to:
- #001 Bulbasaur, in the National and Kanto Pokédex
- #001 Chikorita, in the New Pokédex and the Johto Pokédex
- #001 Treecko, in the Hoenn Pokédex in Generation III and Hoenn Pokédex in Generation VI
- #001 Turtwig, in the Sinnoh Pokédex
- #001 Snivy, in the Unova Pokédex in Black and White and the Unova Pokédex in Black 2 and White 2
- #001 Chespin, in the Central Kalos Pokédex
- #001 Drifloon, in the Coastal Kalos Pokédex
- #001 Diglett, in the Mountain Kalos Pokédex
- #001 Rowlet, in the Alola and Melemele Pokédex in Sun and Moon and the Alola and Melemele Pokédex in Ultra Sun and Ultra Moon
- #001 Pikipek, in the Akala, Ula'ula, and Poni Pokédex in Sun and Moon and the Akala, Ula'ula, and Poni Pokédex in Ultra Sun and Ultra Moon
- #001 Grookey, in the Galar Pokédex
- #001 Slowpoke, in the Isle of Armor Pokédex
- #001 Snom, in the Crown Tundra Pokédex
- Main series:
- Pokémon - I Choose You!, episode 1 of the original series
- Get the Show on the Road, episode 1 of Pokémon the Series: Ruby and Sapphire
- Following a Maiden's Voyage!, episode 1 of Pokémon the Series: Diamond and Pearl
- In The Shadow of Zekrom!, episode 1 of Pokémon the Series: Black & White
- Kalos, Where Dreams and Adventures Begin!, episode 1 of Pokémon the Series: XY
- Alola to New Adventure!, episode 1 of Pokémon the Series: Sun & Moon
- Enter Pikachu!, episode 1 of Pokémon Journeys: The Series
- Mewtwo Strikes Back, the first full-length Pokémon movie
- Pikachu's Vacation, the first Pikachu short animation
- A Family That Battles Together Stays Together!, the first side story episode
- Other anime series:
- Route 1, a route in Kanto
- Route 1, a route in Unova
- Route 1, a route in Kalos
- Route 1, a route in Alola
- Route 1, a route in Galar
- The island named One Island
- The town named One Island
- TM01, a Technical Machine
- HM01, a Hidden Machine
- TR01, a Technical Record
- Cheri Berry, a Berry that debuted in Generation III
- XD001, a Pokémon from Pokémon XD: Gale of Darkness
- ZERO-ONE, a vehicle in Pokémon Snap
- Secret Storage 1, a location in Pokémon Trozei!
- Huge Storage 1, a location in Pokémon Trozei!
- Phobos Mobile No.1: Phobos Train, a location in Pokémon Trozei!
- SOL Laboratory 1, a location in Pokémon Trozei!
- A Glimpse of the Glow, round 1 in the Red, Green & Blue chapter of Pokémon Adventures
- In Search of the Legendary Pokémon Dialga!!, chapter 1 of Pokémon Diamond and Pearl Adventure!
- Deoxys, The Phantom Pokémon! (Part 1), the first special chapter in Pokémon Diamond and Pearl Adventure!
- Pokémon to the Rescue!, chapter 1 of Pokémon Mystery Dungeon: Ginji's Rescue Team
- Pikachu, I See You!, chapter 1 of The Electric Tale of Pikachu
- Hoppip, The Wind Calls!, chapter 1 of Ash & Pikachu
- Prologue: Masara Town, chapter 1 of Pokémon Zensho
- Let's Go! The Journey Towards The Championship, chapter 1 of Pokémon Gold & Silver: The Golden Boys
- The Day Dratini Grew Up, chapter 1 of How I Became a Pokémon Card
- District Convention "Kenta, to the Open Sea", chapter 1 of Aim to Be a Card Master!!
- Behold The Phantom Thief Of Justice, chapter 1 of Phantom Thief Pokémon 7
- The Pokémon Clefairy Enters!!, chapter 1 of Pokémon Pocket Monsters
- Let's Go Catch The Dumpling Thief!!, chapter 1 of Pokémon Ruby-Sapphire
- Enta Arrives at the Battle Frontier!, chapter 1 of Pokémon Battle Frontier
- How Do You Do, Pikachu?, chapter 1 of Magical Pokémon Journey
- A Destined Meeting (chamo!?), chapter 1 of Pokémon Chamo-Chamo ☆ Pretty ♪
- Enter Shū & Pikachu!, chapter 1 of Pokémon Gotta Catch 'Em All
- A Heated Battle Begins!!, chapter 1 of Pocket Monsters Platinum: Aim to Be Battle King!!
- ONE, a CD single by Crystal Kay
- One, a song from the English soundtrack to The Power of One
- Generation I, the first set of Pokémon games
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