In Explorers of Time, Darkness, and Explorers of Sky, Treasure Boxes can be opened at Xatu Appraisal located in Treasure Town for 150 . They contain different kinds of items that range from common food items to rare trade items. In certain dungeons, there will be locked sections in which the player must use a key to obtain the box. There may also be water blocking the box. These boxes will hold items such as legendary specialized items and Wonder Gummis. All boxes, with the exception of end-of-the-dungeon Deluxe Boxes and locked room boxes have random contents, though certain items will be unlocked as the game continues. There is also a chance of a hidden stairway appearing in dungeons, which lead to a hidden room with 5 deluxe boxes and a stairway leading to the next floor.
In Pokémon Mystery Dungeon: Gates to Infinity, the boxes can be opened by Rampardos Box Buster for 150 . Unlike in previous games, Gummis do not exist and Max Elixirs are often obtained instead, although it is still possible to find other items such as held items, and Gold Bars in amounts from one to five. Treasure Boxes can also contain Team Skills. The Team Skill, Collector, enables the player to find more Treasure Boxes from defeated enemies. There is a 15 floor DLC Map named Skill Treasury that enables more boxes to be dropped by defeated Pokémon as well. Boxes can also be found in chambers that either require keys and/or a specific Pokémon type to enter. These chambers can be found with Upgrade 2 of the Detour Guide. Upgrade 3 of the Detour Guide also sells the keys required to enter these chambers for 1650 . These keys can also be bought by exchanging 5 Gold Bars at Glorious Gold in Post Town. Treasure Boxes are stored in a space separate from items in the Deposit Box.