Silph Co. Headquarters
- Main article: Silph Co.
The Silph Co. Headquarters is the largest and tallest building in the city. They are the leading manufacturer of Pokémon technology in the world, and produce a variety of goods for Pokémon trainers, such as the Poké Ball and the Silph Scope. Their status made them a target in the Generation I storyline, in which Team Rocket orchestrated the takeover of their headquarters in Saffron City. The player, though, will arrive just in time to take on the mission of driving them out of the city, and the President of Silph will reveal afterwards the top-secret development Team Rocket was after: the Master Ball, which can catch any Pokémon without fail.
The Silph Co. Head Office Building is an eleven-floor skyscraper, and is effectively a giant maze. People must navigate the building using warp tiles in order to reach different rooms. Some people hold a Card Key, which unlocks Silph's doors like a hotel key. During the events of the Team Rocket takeover, the player must find the Card Key on the fourth floor of the building. All the while, the player must battle numerous Team Rocket grunts, including the Rocket Brothers, and one Juggler. After this, the player may continue on to the board room to face Giovanni for the Master Ball. After driving Team Rocket out of the Silph headquarters, the player is free to explore the building and talk to the employees.
In Generation II, Silph Co. has increased security, and the player is not allowed to enter the upper floors. One of the guards, however, will kindly give the player an Up-Grade for talking to him, which will allow a Porygon to evolve, through a trade, into Porygon2. In Generation IV's HeartGold and SoulSilver, one of the Hoenn region's starter Pokémon may be obtained here towards the end of the game from Hoenn Champion himself, Steven Stone. The alternate forms of Rotom may also be accessed here in Generation IV, and the notebook present in the room Rotom's appliances can be found in indicates that Charon may have had past connection to the company.
Fighting Dojo
- Main article: Fighting Dojo
File:Fdojo.png Fighting Dojo leader accepting a battle in Generation III
In addition to Sabrina's Template:Type2 Gym, there is also a secondary gym, the Fighting Dojo, which has Template:Type2s. It is where, if the Karate Master Kiyo/Koichi is defeated, the player can obtain either Hitmonchan or Hitmonlee in Generation I and Generation III.
It was established that the Fighting Dojo and the Saffron Gym once battled against each other to determine which one would be the Indigo League's sixth Pokémon Gym. Due to the type advantage that the Template:Type2s that were trained at the Saffron Gym had over the Fighting-types used by the Dojo, Saffron Gym easily won and became the official gym.
The Dojo is closed in Generation II, because the leader is training in Johto's Mount Mortar. In Pokémon HeartGold and SoulSilver, the Gym Leaders of Kanto and Johto can be found here for a rematch, much like how the Sinnoh Gym Leaders can be found for a rematch in the Battleground in Pokémon Platinum. Unlike Platinum, the Leaders have set times at which they will appear. However, they will not arrive at the Dojo until certain conditions have been met elsewhere in the game. Specifically, each Leader's telephone number must be obtained while he or she is not in their Gym. Once the Gym Leader has been telephoned, he or she will accept multiple rematches, provided it is still within their allotted time period.
Magnet Train station
- Main article: Magnet Train
In Generations II and IV, the Magnet Train runs from Saffron City to Goldenrod City in Johto, connecting the two regions. It is one of the few methods players can use to travel from region to region, and it will allow rapid travel between the two cities, going at over 340 miles per hour.
To board the train, the player must have a Pass. The Copycat in Saffron City has one, and is willing to give it up as a reward for returning her Poké Doll that a boy gave to her three years before. Initially, the train is out of service as a minion of Team Rocket has stolen a valuable part from the Power Plant in Kanto. After defeating him in Cerulean City, the player can retrieve the part from the Cerulean City Gym and return it to the Power Plant. With the component back in place, the train will have the necessary power to run.
In Pokémon HeartGold and SoulSilver, Vermilion City Gym Leader Lt. Surge will come here and offer to trade his Pikachu for the player's Pikachu. This Pikachu is notable because it originates from a different language than that of the player's game: in the Japanese release of HeartGold and SoulSilver, it is English. While, in the North America release of HeartGold and SoulSilver, it is French.
Mr. Psychic's house
- Main article: Mr. Psychic
Mr. Psychic lives in a house that is located in the southern-eastern suburb of the city. His house is better accessible by entering Saffron City from the southern entrance. He owns a small home, which is only one floor high. In his house there are two pot plants in the southern corners, three bookshelves in the northern corners and a painting on the northern wall. Mr. Psychic sits at a table in the middle of the room. When talked to for the first time, he will say that the player wants a TM and will give away TM29 (Psychic) to the player. This occurs in every generation to date.
Copycat's house
- Main article: Copycat (character)
In Generation I and III, Copycat lives in a house that is located in the north-western suburb of the city. Copycat will give the TM for Mimic, or as a move tutor in Generation III, in return for a Clefairy-style Poké Doll. In her bedroom, there is a Super NES with a game that has Mario with a bucket on his head. In between the events of Generation I and Generation II, Copycat's house in Saffron City was torn down to make room for the Magnet Train station. In Generation II and IV, Copycat's Clefairy doll goes missing, and is found by a member of the Pokémon Fan Club in Vermilion City. When the player returns her lost doll, Copycat will reward them with a ticket to ride the Magnet Train that travels between Kanto and Johto.
Pokémon Trainer Fan Club
People gather to discuss their favorite celebrity trainers at the Pokémon Trainer Fan Club, which only exists in Generation III.