It will also hit the target even if it is protected by Protect, Detect, Spiky Shield, King's Shield, Mat Block, or Baneful Bunker, and lifts the effects of those moves for the remainder of the turn; if it hits a target that is protected by Mat Block, it removes Mat Block from the target's side of the field. It also removes the effects of Quick Guard, Wide Guard, and Crafty Shield from the target's side of the field. Hyperspace Hole cannot remove the effects of protecting moves if it does not affect the target (such as if the target is Dark-type). It hits through a substitute.
It breaches an enemy's Protect, Detect, etc., and it hits without fail.* It breaks through the enemy's Protect, Wide Guard, Quick Guard, Mat Block, King's Shield, or Spiky Shield to damage the enemy. It never misses.*