A bottle of Heal Powder appeared in The Brockster Is In! as one of the items gathered from the passengers of a cruise ship to help cure the poisoned Pokémon Normajean was taking care of.
Heal Powder was released as a Trainer card in the Neo Destiny expansion, first released in the Japanese Darkness, and to Light... expansion. It features an illustration by Ryuta Kusumi and CR CG gangs. It allows the player to flip a coin. If they flip a head, their Active Pokémon is no longer Asleep, Confused, Paralyzed, or Poisoned and 2 damage counters are removed from it (if it has only one, that damage counter is removed).