Mind Blown inflicts damage, and the user takes damage equal to half of its maximum HP rounded up (unless it has Magic Guard). Mind Blown cannot be used when a Pokémon with the AbilityDamp is on the field.
The user of Mind Blown will take damage even if the target is protected from it, if it hits a substitute, if the move misses, or if the target has Flash Fire. If Mind Blown fails due to there being no targets (i.e. if all Pokémon in range fainted before the move was used), the user does not take damage.
Rock Head and Reckless do not affect Mind Blown. If the user has Parental Bond in a Single Battle, the HP loss occurs after the first hit, and the second hit will only occur if neither Pokémon has fainted as a result. There is no additional HP loss for the second hit in that case. The user loses if all of the last Pokémon faint in the same turn as the result of using Mind Blown.
Mind Blown does not exist in the game data of Pokémon Sun and Moon. As a result, a Pokémon knowing Mind Blown cannot be traded from Pokémon Ultra Sun and Ultra Moon to Sun and Moon, and if a Pokémon in Pokémon Bank knows the move it cannot be withdrawn in Pokémon Sun and Moon. In order to be transferred to Pokémon Sun and Moon, the Pokémon must forget Mind Blown. However, because Blacephalon also does not exist in Pokémon Sun and Moon, this restriction is only applicable to Smeargle.
If a Shiny Pokémon uses Mind Blown, the move's animation is different, appearing to use a Shiny Blacephalon's blue head rather than the normal white one. This makes it one of only two moves whose animation differs depending on if the Pokémon is Shiny or not, the other being Dragon Darts.