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The first time a Chansey appeared under Joy's ownership was in Pokémon Emergency!. Two Chansey wheeled Ash's Pikachu into the emergency room after he was injured badly from a flock of Spearow Ash was protecting Pikachu from. Since then, they have been featured in nearly every Pokémon Center until the Best Wishes series, during which Audino were featured instead as Chansey is not native to Unova.
Several Chansey have appeared more prominently than others. The one owned by the Nurse Joy in Overjoyed! was not only a good nurse, but a good battler as well. She was able to defeat Ash's Corphish in an informal battle the two had. Another Chansey, in The Joy of Pokémon, traveled on a kayak with her Nurse Joy from island to island to treat injured Pokémon. Jessie of Team Rocket once befriended a Chansey, which later met again, having evolved into Blissey. She appeared in Ignorance is Blissey.
One of them was used in SS025 where she was used under the ownership of a PIA Nurse Joy. She battled Brock's Sudowoodo at the Pewter Gym. Sudowoodo fell for Chansey's Attract and was defeated with an Egg Bomb; not laying a single hit. After a long absence, another one appeared in SS027.