Nosepass first appeared in Blowing Past Nosepass I, when Roxanne sent it out during her Gym battle against Sapphire's Rono. Despite the type-disadvantage, it managed to overwhelm Rono when Magnet Pull prevented him from switching out and moving. From that point on, Nosepass used a combination of Rock Throw and Rock Slide to defeat Rono. However, Sapphire figured out Nosepass's weakness as it would usually face north and stay that direction. With Nosepass facing the other way, Rono was able to escape the rubble and defeat Nosepass.
Roxanne usually keeps Nosepass's Poké Ball in a hollowed-out book. During battle, it knew some techniques that prevent the opponent from escaping. However, only a few, such as Sapphire and Courtney, know their way around it.
Nosepass appeared in The Winner by a Nosepass, where Roxanne used it in a Gymbattle against Ash. As Pikachu became worn out after battling her Geodude and had trouble with his Iron Tail technique, Nosepass was able to get the upper hand. However, Nosepass struggled to keep up with Pikachu's speed after he used Quick Attack to dodge. Later, it unknowingly sent Team Rocket blasting off after using Zap Cannon and made a hole in the battlefield. Even though Pikachu started to get tired even more, a Zap Cannon blast from Nosepass recharged him and the Compass Pokémon was defeated by Pikachu's Iron Tail attack, which earned Ash the Stone Badge.
Very little is known about Nosepass's personality, as it was only seen during its Trainer's Gymbattle with Ash. However, it has no problem obeying Roxanne's orders, as seen during the entirety of its time in the match against Pikachu. Compared to Roxanne's Geodude and Ash's Pikachu, Nosepass was slower than the both of them. However, it proved to be a challenging opponent, with its Sandstorm and Rock Tomb attacks giving Pikachu a hard time.
Nosepass appeared in Trust In Each Other!!. After Roxanne's Geodude lost to Pikachu's Iron Tail, Nosepass was the next opponent Pikachu faced. Nosepass had very little trouble at first with the battle as Pikachu hadn't mastered Iron Tail. However, despite Nosepass's combination of Rock Tomb and Sandstorm, it struggled to keep up with Pikachu's speed. Nosepass was defeated when Pikachu successfully mastered Iron Tail and got charged by Zap Cannon.