The Kanto Pokémon Federation first appears in Pokémon Gold, Silver, and Crystal as an affiliation of three Bikers on Route 8. The Underground Path on their route was shut down by the police after they (presumably) wrecked it. Their overworld sprites differ by color: Dwayne's is red, Harris's is green and Zeke's is blue.
Trainers with a telephone symbol by their names will give their Pokégear number to the player, and may call or be called for a rematch with higher-level Pokémon.
In Pokémon FireRed and LeafGreen, the group is known as Kanto Rider Federation (Japanese: カントーれんごうKanto Federation). They are formed by eight members, here called Goons, and their boss, who are found trying to take over Three Island, terrorizing its citizens. To fight them, the player must first go to Joyful Game Corner, where one of the members will show up looking for his teammates.
The Kanto Federation appears in A Vicious Cycle of Possibilities. Having arrived at Three Island, they were attempting to vandalize Berry Forest. On their way, they found Lostelle, who was looking for her Dunsparce. Their boss threatened the little girl, grabbing her in the air. To stop them, Deoxys appeared and smashed the group and their motorbikes. Their boss then heard someone stepping by and asked for help, but the man scorned him instead.
The following is a list of Pokémon owned by the Federation.