In battle
Run Away guarantees escape from a wild Pokémon, negating any trapping move or ability from the opponent in effect, such as Mean Look and its variations, Wrap and its variations, Shadow Tag, and Arena Trap. However, Run Away does not allow a Pokémon to switch out when a trapping move or ability is in effect, even in a wild Pokémon battle. Run Away has no effect in trainer battles. When activated, the message "<Pokémon name> escaped using Run Away." will appear.
In Pokémon Mystery Dungeon and the sequel, a Pokémon with Run Away will become terrified and run from all Pokémon when its HP is down below ½. Leaders are unaffected.
Outside of battle
Run Away has no effect outside of battle.