Comfey debuted in First Catch in Alola, Ketchum-Style!, where it put its lei around Ash's neck soon after Ash first came into contact with it. It also assisted Nurse Joy in treating Pikachu.
Like most of Nurse Joy's Pokémon, Comfey is a helpful and caring Pokémon and is always ready to help injured or sick Pokémon. As shown in First Catch in Alola, Ketchum-Style!, it had no problem sharing its lei with Ash, which soothed the Trainer with its aroma.
Comfey is shown to be concerned for Nurse Joy, as seen in Real Life...Inquire Within! where it tried to help her get better when she became ill.