Crystal first met Parasee when she was training to be a capture pro. It is there where an Arcanine was rampaging out of control due to an eye injury. Due to this, Crystal fell and broke her arms. After waking up she saw a Parasect and Cubone, who had used Spore to numb her pain and bones to make a makeshift cast. After assessing the situation they led Crystal to the Arcanine and she managed to calm him down, using Parasect's spores to help heal him. Crystal then adds them to her team.
Parasee first showed up in Slugging It Out with Slugma alongside Crystal's other Pokémon to help prove her capturing skills to Professor Oak.
In Indubitably Ditto, Parasee used Spore over a long range in order to stop the Team Rocket Elite Trio from chasing Suicune, allowing Crystal to get to it first.
In Suddenly Suicune I, Parasee battled Suicune to try and help Crystal capture it. Parasee used Spore to put Suicune to sleep. Suicune pushes some of the spores away with Gust but fails to remove them completely. With no other choice Suicune jumps for the pond below them, but Monlee jumps and falls past Suicune and uses Mega Punch on the ground. The attack fractures the ground, throwing Suicune into the air and battering it with boulders. Despite all the damage Suicune ends up escaping in the end.
In Slick Slowking, Parasee battled against Sham and Carl alongside Gold's Sunbo. The two attack with Giga Drain, sapping the health of their opponents and knocking them out. After the battle the Trainers realize they are trapped inside, and Parasee uses the powders inside her body to create a powder that will cause corrosion. Once done she combines the mixture with Sludge Bomb, melting the door and allowing them to escape.
In The Final Battle II, Parasee was seen helping stop Guile Hideout from escaping.
In Pleased as Punch With Parasect, Parasee used her spores to heal Silver of his wounds. She healed him again later in All About Arceus V.