This article is about an episode of the Pokémon anime that has not yet aired anywhere in the world. As such, it is a reflection of what is currently known about the episode, rather than coverage of the episode as a whole.
Team Plasma carries out a massive attack on the Castelia City masquerade party and steals the Meteonite from Team Rocket, hoping to use it to control Pokémon into turning against their Trainers. While Giovanni, Pierce, Dr. Zager, and the rest of the team fall back, Jessie, James, and Meowth are sent to pursue Team Plasma back to the Desert Resort, where a great conflict breaks out. However, during the fighting, the Meteonite becomes unstable and begins releasing large blasts of energy that power up the two teams' Pokémon but also creates an imbalance in nature.
Looker and Professor Juniper escort Ash and his friends to the Desert Resort in hopes of stopping the Meteonite and getting Pikachu back to normal. As they arrive, they discover that the situation with the Meteonite has escalated into a disaster that threatens to destroy all of Castelia City. Ash and Pikachu battle to overcome both Team Rocket and Team Plasma while finding a way to stop the Meteonite from destroying Castelia City.
The depiction of Team Plasma in these episodes differs significantly from how they would be depicted from their official debut in Team Plasma's Pokémon Power Plot! and onward. While they still want to put Pokémon under mind control, the Team Plasma Grunts in these episodes state their desire is to liberate Pokémon from their Trainers and that they're doing this in service of "the hero." This suggests a different story arc based on the first games of Generation V was planned for the first incarnations of Team Plasma to feature in but it got scrapped as of the release of the sequels, the anime using the second incarnation of Team Plasma instead.
The scene with Liepard attacking a skyscraper with Hyper Beam with two Team Plasma Grunts alongside it on a helicopter is reused for the Best Wishes! Season 2: Episode N opening, Be an Arrow! 2013, although it is newly animated rather than taken directly from the episode. The differences is that Aldith and Barret are in the scene (who have their uniforms designs from Black 2 and White 2) instead of one Team Plasma Grunt with the original Black and White uniform.