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Anna lives in the mountains along with her grandfather Oscar. They were on a hike in the mountains when she fell. Oscar tried to save her with his Stoutland, but when Oscar was about to pull her back up, the three fell and were about to meet their end, until Mewtwo arrived and lifted them back up. When Virgil arrived at their house to make an emergency landing with his helicopter, Anna told him the story about Mewtwo.
Later, the three of them, along with a mysterious man named Dirk, who had also encountered Mewtwo, went to the mountains to find Mewtwo. Anna has a connection with the Pokémon of the forest and was able to summon them to help search for Mewtwo. They eventually found it and discovered Dirk had plans of capturing Mewtwo. Together they thwarted his plans, however.