The animation begins with Ash, Iris, and Cilan running down a long corridor while multiple arrows of various colors fly in the direction they're running towards. A glowing arrow flies around the screen until it turns into Ash and Pikachu with an orange pillar in front of them. A second arrow swirls around and turns into Iris and Axew with a purple pillar next to them. A third arrow turns into Cilan with a green pillar underneath him. A fourth arrow apprears then Ash with Pikachu on his shoulder, Ash throws a Poké Ball up, it opens and flashes revealing the "Best Wishes! 2" logo.
The scene changes to several Pokémon from varying generations running through a grassy field. After changing to a different group of a Pokémon, Ash, Iris, and Cilan are seen running near a body of water with several Pokémon swimming near them. As they continue running, Meloetta enters the scene and playfully steals Ash's hat. The scene moves to Professor Oak's laboratory, where Professor Oak, Delia Ketchum, and Tracey stand in the field of Ash's various Pokémon. When Charizard is shown onscreen, it turns around to give a thumbs up.
Ash then runs into an area resembling some ruins. As he runs, multiple stone pillars suddenly erupt from the ground, forcing Ash to jump back. Ash looks back to see Pikachu jumping in to destroy the pillars with Thunderbolt. Pikachu is successful, and gives Ash a peace sign to show his satisfaction. Elsewhere, a Keldeo begins glowing as it stands on top of a large block of ice with Cobalion, Terrakion, and Virizion. A wall of ice breaks to reveal Kyurem, who then causes a split screen to show Black Kyurem and White Kyurem.
Stephan and his Sawk do several karate poses. Trip poses with his Serperior. Bianca and her Emboar run through a city, only to clumsily fall onto their faces. Ash, Iris, Cilan, Dawn, Trip, Stephan, and Bianca all pose with their Pokémon, only to quickly fly into the air as if they were using Quick Attack. They all fly towards a building and combine into a giant arrow that collides with it. The animation ends with a group shot of Ash, Pikachu, Iris, Axew, Cilan, and Ash's Pokémon.