Sometimes after event of Ash's Journeys, Latios already left the Alto Mare though he is still stubborn since he distrust humans. Latios arrived at the Blood+ World, he notices that Saya is reawakened too early because of the Disruption Dimension Energy, created from Demonious' hatred appears to search and destroys Samuel Nakaoka who still lives on Skye Zaizen's body for destroying his existence. Realizing what it after, he then headed towards the Yu-Gi-Oh! World where Samuel still lives.
Personality and characteristics
He is very stubborn Legendary Eon Pokemon because he didn't trust humans.
Following the events of QuadStrike arc, Latios slowly begin to trust humans after learns that Saya and Diva are like twins like his sister Latias. After Diva asked Latios to join Samuel's group, he happily decide to do so.