So the Galar Region has just been announced for Pokemon Sword and Shield, and I know there were rumours before the announcement that it would be based off of the UK, so as a Briton myself, I've tried to verify that/match the locations. The industrial and farming focus definitely suits the UK, and I can see a structure that looks like the Palace of Westminster in the Icy Northern City, suggesting the island is flipped North to South (and possible East-West as well).
Based on this, looking at the red-brick city in which the starters are shown, with its industrial nature, canal leading to the sea and bordering mountains, I think that it represents Manchester, which would mean that the city by the wall where the ice starts would be Birmingham, although none of it's features match.
It's also possible the city on the sea is Liverpool, due to being on the coast between Manchester and Birmingham.
The industrial City being Manchester also fits with the lakes South of it, which would represent the Lake District
These cities would suggest that the region represents just England, rather than the whole of the UK.
Just some preliminary ideas, we shall have to wait for more information before confirming anything.