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* While widely regarded as the most powerful Pokémon, Mewtwo's moveset upon capture in {{game|HeartGold and SoulSilver|s}} is incredibly weak, with only one damaging move, itself a [[physical move]], and three status moves that only affect stats, completely counter to Mewtwo's moveset upon capture in all previous games in which it was available, which featured {{m|Psychic}}, {{m|Recover}}, {{m|Swift}}, and another status move. It is unknown why Mewtwo's level-up learnset was not altered between DPPt and HGSS considering that this happened to both Lugia and Ho-Oh, its equals in terms of stats, and also happened between RSE and FRLG for its own learnset. | * While widely regarded as the most powerful Pokémon, Mewtwo's moveset upon capture in {{game|HeartGold and SoulSilver|s}} is incredibly weak, with only one damaging move, itself a [[physical move]], and three status moves that only affect stats, completely counter to Mewtwo's moveset upon capture in all previous games in which it was available, which featured {{m|Psychic}}, {{m|Recover}}, {{m|Swift}}, and another status move. It is unknown why Mewtwo's level-up learnset was not altered between DPPt and HGSS considering that this happened to both Lugia and Ho-Oh, its equals in terms of stats, and also happened between RSE and FRLG for its own learnset. | ||
* An image of Mewtwo is seen on the door [[Bill]]'s light house in ''[[EP013|Mystery at the Lighthouse]]'', which would mark it first minor appearance in the anime, as well as implying that Bill knows about the creature. | * An image of Mewtwo is seen on the door [[Bill]]'s light house in ''[[EP013|Mystery at the Lighthouse]]'', which would mark it first minor appearance in the anime, as well as implying that Bill knows about the creature. | ||
* Mewtwo is the first, and currently the only Pokémon created by {{wp|Genetic engineering}}. | |||
===Origin=== | ===Origin=== |
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