Mr. Mime is a bipedal, humanoid Pokémon. Blue growths resembling clown hair extend from the sides of its pale pink head, and there is a magenta circle on each cheek. Its jaw is curved inward, resembling the mouth of a wooden dummy. It has a round, white body with a magenta spot in the middle, light pink arms and legs that connect to its body via magenta spheres, and small white coverings over its knees. Its white hands resemble gloves with magenta pads on the tips of its white fingers and its dark blue feet curl upward at the tips.
From birth, this Pokémon is an excellent pantomime. As it matures, it gains the ability to solidify air molecules by vibrating its fingertips. This ability allows it to create invisible objects with its gestures. It punishes those who interrupt its act or are not impressed by slapping them. Mr. Mime is usually very rare, but can be found in suburban areas. In the past, Substitute was its signature move.
Mr. Mime made its main series debut in It's Mr. Mime Time. Ash and his friends came across it while looking for a Mr. Mime to replace another one that was supposed to perform in Stella's circus. It was later taken in by Ash's mother Delia after it arrived at her house and she mistook it for Ash in a costume.
Another Mr. Mime appeared in It's Mr. Mime Time as one of the Pokémon in Stella's circus. However, it was lazy and stopped obeying her because she was too hard on it. It eventually listened to her once more when it saw how much she was willing to protect it from Team Rocket.
A Mr. Mime appeared in Stage Fight!, where it was part of a showboat stage show along with other Pokémon.
A Mr. Mime appeared in Hail to the Chef, under the ownership of Rhonda, a girl who lives outside Saffron City. She was competing with her sister Rhoda, who owned a Sneasel, for the ownership of her father's restaurant. Mr. Mime's cooking made the food taste horrible, but with help from Brock, its cooking improved.
Valerie owns a Mr. Mime in Quilladin Stands, where it was used to help stop the Ultimate weapon from activating. Bryony's familiarity with the tactic used by Valerie's Mr. Mime, by means of referring to pages from an encyclopedia, is a direct reference to the two occasions the tactic was previously used in Pokémon Adventures.
A Mr. Mime appeared in Detective Pikachu, where it was encountered by Detective Pikachu and Tim Goodman at Ryme Wharf while they were searching for the source of the R substance. Having previously been interrogated by Tim's father Harry and Detective Pikachu before, it tried to mime an escape but was unsuccessful. Tim and Pikachu then tried interrogating it, but it taunted them and used Barrier to shield itself from any other questioning. This prompted Tim to try and "get inside its head", and he mimed opening the door to Mr. Mime's "room", pouring gasoline on it, and threatening it with a mime lighter. Mr. Mime relented and revealed that it had gotten the R from the "roundhouse", an illegal fight club owned by Sebastian. In their excitement, Tim accidentally dropped the "lighter", much to the Mr. Mime's horror.
Pokémon Stadium 2: Mr. Mime stars in its own minigame called "Barrier Ball." Poké Balls appear on the field and by using Mr. Mime's Barrier, send the Poké Balls to the other player's fields.
In all official artwork and in-game sprites prior to the release of Pokémon FireRed and LeafGreen, Mr. Mime only had four fingers. However, Mr. Mime has always had five fingers in the anime.
Mr. Mime appears to be based on a combination of a clown, a mime artist, and the pantomime of pretending to be trapped in invisible boxes. Its feet also appear to be reminiscent of the various hook-toed shoes worn by jesters. Its jerky animations and jaw suggest that it may also be a tsukumogami of a jointed puppet, dummy, or doll.
Mr. Mime is mime with an English male honorific. This gendered name was assigned before the gender mechanic was introduced in the games and is not reflected by the species' gender ratio.
Barrierd may be a combination of barrier (referring to the mime trait of 'being trapped' behind invisible walls) and weird or barricade.