Slurpuff debuted in A Battle by Any Other Name!, taking one of Serena's Poké Puffs with Psychic. Later during the Poké Puff Contest, Miette used Slurpuff as her assistant during the preliminary rounds. After proceeding to the final round along with Serena and the Berrybaker kids, Miette and the group went to a nearby forest to look for Berries to use as Poké Puff ingredients, using Slurpuff's accurate sense of smell to locate them. Upon finding some fresh Berries, the group also found Team Rocket, trying to steal the Berries with their mecha. Slurpuff then proceeded to help Ash and his friends' Pokémon to get rid of Team Rocket and recover the Berries they had stolen. The next day, Slurpuff assisted Miette in the final round of the Poké Puff Contest, but to both Miette and Serena's surprise, the Berrybaker kids were victorious instead of either one of them.
Slurpuff reappeared in Performing with Fiery Charm!, performing along with Miette's Meowstic in the Dendemille Town Pokémon Showcase, first in Poké Puff Baking Theme Performance and later in a Freestyle Performance.
In Party Dancecapades!, Slurpuff accompanied Ash's Pikachu in a dance party hosted by Monsieur Pierre, while Ash acted as Miette's partner. Later, she participated in a Tag Battle alongside James's Inkay, facing Ash's Pikachu and Serena's Eevee. During the battle, Serena's emotions towards Eevee allowed her to evolve into Sylveon. Sylveon then proceeded to defeat both Slurpuff and Inkay with its newly learned Fairy Wind.
Slurpuff reappeared in Master Class is in Session! and Performing a Pathway to the Future! as the Pokémon Miette used during the Gloire Master Class Pokémon Showcase. Their performances were enough to carry them on to the semifinals along with Serena and Jessilee, but eventually Serena was the one who made it to the finals to face Aria.