In Super Smash Bros. Brawl, Manaphy uses Heart Swap when coming out of a Poké Ball. This switches the controls of the players of the two characters closest to Manaphy when it launches the attack. Damage meters are also swapped, and if a character is knocked out, the player controlling the character at that time loses a stock (instead of the player who originally controlled that character). After approximately 15-30 seconds, the controls will be returned to normal.
Manaphy has a possibility of being able to swap four brawlers' hearts if all four are close enough to it.
The ends of Manaphy's antennae glow pink and each produce a pink energy from them. The two energy balls find a Pokémon or human, and when both energies touch the opponent, their souls are switched. The switched bodies have their own voice, and their eye color changes to light blue. After a while, the effects fade.