In Black and White, when the player reaches the pond in the middle of the crater, the forest will freeze and be completely covered in snow, thus giving the player access to the cave Kyurem is hiding. Once the player has captured or defeated Kyurem and left the area, the snow will disappear, and the northern portion of the caves will no longer be accessible. If Kyurem is defeated, however, the area will become accessible again after entering the Hall of Fame once more and returning to the pond in the center of the crater.
In the years between Black and White and Black 2 and White 2, the path from Lacunosa Town to the Giant Chasm has been blocked by a landslide. A lone boulder blocks the path, which can be pushed with Strength from the Giant Chasm's exterior.
In Black 2 and White 2, the player encounters Team Plasma here. Two Team Plasma Grunts block a path inside the east of the cave until the Plasma Frigate arrives on top of the crater's forest after the player has beaten Zinzolin aboard the ship while it's docked on Route 21. The frigate freezes over many of the trees, creating an icy hill on top of which the frigate is docked. Rood of the Seven Sages along with several old Team Plasma members confront the new Team Plasma; this gives the player the opportunity to sneak aboard the Plasma Frigate, where they battle against Colress and run into Ghetsis. The player follows Ghetsis out of the ship after defeating the Shadow Triad. At the end of the cave, Ghetsis appears and tries to freeze the player alive with Kyurem's Glaciate, but are saved by N and his ZekromB2/ReshiramW2 flying down from above. Ghetsis reveals he tricked N into coming here so Ghetsis could fuse Kyurem with N's dragon, before using his cane to control Kyurem, who proceeds to fuse with N's dragon with the DNA Splicers, forcing the player to fight BlackB2/WhiteW2 Kyurem. Upon winning the battle, ZekromB2/ReshiramW2 will be separated from Kyurem and return to N, and Kyurem will disappear from the cave. Afterwards, the player fights Ghetsis himself.
After defeating Ghetsis, he descends into madness, causing the Shadow Triad to appear and take him away, leaving his cane. Outside, the Plasma Frigate has left. Rood and his team wait to tell the player that Colress has disbanded the new Team Plasma and taken the Plasma Frigate. Unlike the previous games, Giant Chasm's upper craters will not become permanently inaccessible because the parts in the original game that blocked the way after catching Kyurem have been removed, specifically the one-way ledge outside the back cavern.
Giant Chasm appeared in The King Returns, where Ghetsis was seen there with Kyurem, commanding it to cover all of Unova in ice. However, he was interrupted by N arriving with Reshiram, wanting to protect the place that had taught him how humans and Pokémon can live together. Ghetsis then used the DNA Splicers on Kyurem, allowing it to absorb Reshiram and turn into White Kyurem. He then ordered Kyurem to attack N, but N was saved by the sudden arrival of Hilbert and Zekrom, who had arrived to help stop Ghetsis.
In Giant Chasm, the UnovaPokédex holders, pursuing Team Plasma, arrived there as well. Upon arrival, they met Iris and Gorm, learning that Iris had become the new Champion of Unova after defeating Alder and N. Colress then appeared and had Kyurem attack the group with Freeze Shock, freezing the entire Giant Chasm over in the process. However, Colress suddenly lost control of Kyurem, and Rood, arriving at the scene, informed him that the white Team Plasma had activated a device that was neutralizing the Colress Machine's ability to control Pokémon. Freed of Colress's control, Kyurem ejected the Dark Stone from its body and absorbed Reshiram, turning into White Kyurem. Seeing that Kyurem was no longer under his control, Colress decided to quit Team Plasma and escape. While Blake pursued Colress, Black, White, and Iris tried to stop Kyurem from destroying the Plasma Frigate, since N was still inside it.
In The Final Battle: Crushed Ambition, Kyurem separated from Reshiram and left, only returning briefly afterwards to freeze Colress after he had been defeated by Blake, allowing Blake to arrest him. Once all the humans had left Giant Chasm, Kyurem covered the entire location in ice in order to rest undisturbed.
The Giant Chasm and its lore seem to have been inspired by the real-life Tunguska event. A shard of comet struck the Siberian taiga, forming a huge crater and felling trees for miles. Like how Kyurem is thought to have fallen on a comet, and how the Plasma Frigate destroys the forest, the Tunguska event is surrounded by conspiracy theories of aliens and weapons testing.