In One Big Happiny Family!, while traveling on Cycling Road, the Egg began to glow. After taking it to a Pokémon Center and receiving assistance from Nurse Joy, the Egg hatched into Happiny. Soon after birth, she began crying for a stone to hold as a fake Egg. Brock found a white stone and polished it into an Oval Stone for her. Team Rocket snatched Happiny away before he could give the stone to her. Eventually, Happiny was returned to Brock and received her "Egg". Immediately after, she returned it to Brock as a sign of friendship. He gave it back to her and then caught her in a Poké Ball.
In Tanks for the Memories!, Happiny learned how to use Secret Power to save Autumn and Ilta from a group of Beedrill. She also used Secret Power later in the episode to put Team Rocket to sleep so that Brock and Autumn could escape.
Brock was going to use Happiny in her first battle against Marilyn's Shellder in Battling a Cute Drama!. However, right before the battle started, Team Rocket interrupted and tried to steal Marilyn's other Pokémon. Before they could succeed, Happiny was able to send them flying with her powerful Pound attack.
In Dealing With a Fierce Double Ditto Drama!, Happiny was used in her first battle by Brock, where she participated in a training round against Narissa's Ditto One and Ditto Two. Both Ditto Transformed into Happiny and used Pound, pushing Happiny back. She retaliated with a Pound of her own, which sent the Transform Pokémon flying into the nearby forest. The battle was called off.
Like most baby Pokémon, Happiny became very attached to her Trainer very quickly. She would become upset whenever she was taken out of Brock's care and refused to cooperate with Team Rocket completely. Unlike Bonsly, however, she did not cry or fuss; she actually fought back against Team Rocket's Pokémon after Brock had been hurt.
Happiny had extraordinary strength for a baby Pokémon. Examples of this appeared in Bibarel Gnaws Best!, where she carried many heavy boulders, and in A Maze-ing Race! and Crossing Paths, where she lifted and threw large boulders. She saved Team Rocket, Dawn, and their Pokémon from falling in Journey to the Unown!, and saved Brock and Autumn from falling off a bridge by hurling them high through the air to the other side of it in Tanks for the Memories!. She was also seen walking in Canalave City while lifting Ash's Grotle—who was tired due to its new large size after evolving—with one arm in Jumping Rocket Ship!. She was also able to stop Dawn's Piloswine from rampaging in A Breed Stampede! with her strength. Later, in Leading a Stray!, when Mamoswine tossed Dawn up into the air, Happiny caught her just in time. It is unknown if she has retained her unusual strength following her evolutions, but she was shown to be a competent conventional battler as a Blissey.
The only times where her strength was not enough were in Leading a Stray!, where she failed to pull off a tight manhole cover, in The Psyduck Stops Here!, where she tried to lift a massive boulder but collapsed under the weight, and in Regaining the Home Advantage!, where she attempted to stop a rampaging Metagross but was flung backward. Any other time, she successfully brought out her special and uncommon power.