Vespiquen is a four-foot-tall bee Pokémon with a yellow and black striped abdomen that resembles an elegant ballroom gown. The underside of her expansive abdomen has sections like honeycomb cells, and can serve as a nest for baby Combee. It does appear, however, that she has a regular, slender insect abdomen in the centermost cell, which is inconspicuous as the ‘skirt’ usually obstructs the view of it. She has black, skinny arms with two orange claws and flies with a pair of small (compared to her body) wings on her orange shoulders. She has a nearly spherical yellow-colored upper body and a slender black waist. Vespiquen also has an orange face with red intimidating eyes, oversized, yellow-colored protruding mandibles, a red gem on her forehead that has grown significantly since she was a Combee and a headpiece of sorts with yellow and black "horn" like projections, resembling hairstyles favored by early English queens.
Vespiquen are queens of hives of Combee, controlling it and protecting it, as well as giving birth to young Combee. A Vespiquen is far more powerful than her followers, and will only take action if her Combee are unable to protect the hive. If outsiders prove themselves to the Vespiquen by defending her hive, she may repay their acts of kindness with a reward.
Vespiquen live in huge hives in the forests with their Combee followers.
| colspan="13" | Bold indicates a move that gets STAB Italic indicates a move that gets STAB only from an evolution of this Pokémon A colored initial indicates that the move is not available to be tutored in this game, while a colored background indicates that the move is available.
Vespiquen is the only Pokémon introduced in Generation IV whose name starts with the letter "V".
Vespiquen's name, despite being based on the word "queen", only has one "e" in its second half, even though another "e" could have fit in perfectly without exceeding the 10-letter Pokémon name limit. The reasons for the single "e" are unknown.
Its name is derived from the words vespa, both a genus name and Latin for wasp, and queen. The name Beequeen is derived from the word bee and queen, referring to the fact that only female bees can become the leader of a colony of bees.
In other languages
German: Honweisel - From Honig (honey) and Weisel (queen bee).
French: Apireine - From apis (Latin for bee) and reine (queen).