In the games, Mt. Silver is off-limits to all but the most skilled of Trainers. After Ethan or Kris has received all sixteen badges of Johto and Kanto, Professor Oak will give him or her permission to travel here.
The route to the area is rough, though no HMs are explicitly required to reach the Pokémon Center just outside the entrance. Inside, however, the cave is dark, requiring Flash to see. Many high-level Pokémon reside in the cave, including rare Pokémon not found elsewhere in the Johto region, like Larvitar and Misdreavus.
The cave has only one entrance, unlike all other caves found in Pokémon Gold, Silver, and Crystal, but goes deep into the mountain. In the cave's final room, the player will encounter a familiar face who will, wordlessly, challenge him or her to what is the highest-leveled Trainer battle in the history of the Pokémon series.
In HeartGold and SoulSilver, Mt. Silver is much larger. The higher sections of the cave where Red is located require Rock Climb to access. At times the player must also venture onto the slopes on the mountain's sides in order to climb higher.
In the anime, Mt. Silver is the home of Silver Town, a city that boasts at least 30 inhabitants. Silver Town's main attraction is the Silver Conference, the Johto League's yearly tournament that brings tourism to the city. Oddly, the anime depicts the mountain to be much smaller than shown in promotional maps.
Later, Red and Gold leave to Mt. Silver to train together.
Though Mt. Silver appears relatively deep into Kanto, it is identified as a Johto location by the Pokégear.
Mt. Silver was called Shirogane Mt. in the Gold and Silver deluxe edition of the Pokémon Master Trainer board game. Because its release predated that of the games, it used the Japanese name.
Despite appearing to be closer to the Johto-Kanto border on the Pokégear map, the entrance to the Pokémon Center is 17 steps from the border when factoring in only horizontal distance, making it 10 steps farther from Kanto than the doorway of the player character's house.
Red's Pikachu, who can be fought here at level 88, is the highest-leveled Pokémon of any in-game Trainer in the series. However, this only applies to HeartGold and SoulSilver as Red's Pikachu is at level 81 in the original Gold and Silver (and by extension, Crystal).
In the original player's guide to Gold and Silver, there is mention of a "?" Pokémon that appears near the waterfalls in Mt. Silver at midnight or very early in the morning; however, this is a false rumor. The guide also claimed that the unknown Pokémon was supposed to represent legendary Pokémon found in Generation I that did not appear in Gold and Silver (which were programmed in and tradable from Generation I anyway).
Like Snowpoint City, Mt. Silver's summit features diamond dust on certain special days in Generation IV, including the anniversary of Gold and Silver's original release.
If Red is engaged in battle on a day with diamond dust, there will be no Hail condition during the battle. As no battles could be conducted in Snowpoint City's diamond dust, this is the first indication of its in-battle effect.
Mt. Silver is marked as a Johto location by the Pokégear; however, all squares immediately surrounding it (including those to the west of it) are marked as Kanto areas by the Pokégear in Generation IV. This issue was not present in the Generation II map, which placed it directly above New Bark Town.
The exterior of Mt. Silver is the only Johto area with Kanto characteristics, like the rocks, tall grass, trees, and the Pokémon Center itself. However, in Generation IV, the only major differences are the rock and trees.
Strangely, in Generation IV, the trees placed in the high exteriors of the mountain itself are the ones commonly found in Johto.
In Generation IV, despite locations nearby, such as the Route 26 entrance to the Pokémon League and the Indigo Plateau itself being able to be flown to from either Kanto or Johto, and players already there being able to fly to either region, Mt. Silver is strictly a Johto location, while Route 28 is strictly a Kanto location. This means that a player cannot fly to Mt. Silver from Route 28 (if he or she has already been to the Pokémon Center outside) even though one can walk between the two locations rather easily.
The regions of Kanto and Johto, as well as Mt. Silver, are also shown on the Orange Archipelago map. Interestingly, the mountain lies within the same meridian as Shamouti Island, one of the archipelago's important islands.