Mr. Mime is a bipedal, humanoid Pokémon with a round, white body with a magenta spot in the middle. Its light pink arms and legs are connected to its body by magenta spheres. Its knees have small, white coverings. There are magenta pads on the tips of its white fingers, and its dark blue feet curl upward at the tips. Blue growths resembling clown hair extend from the sides of its pale pink head, and there are magenta circles on its cheeks. Its jaw is curved inward, resembling the mouth of a wooden dummy.
From birth, this Pokémon is an excellent pantomime. As it matures, it gains the ability to solidify air molecules by vibrating its fingertips. This ability allows it to create invisible objects with its gestures. It punishes those who interrupt its act or are not impressed by slapping them. Mr. Mime is usually very rare, but can be found in suburban areas.
Mr. Mime made its main series debut in It's Mr. Mime Time. Ash and his friends were looking for a Mr. Mime to replace another one that was supposed to perform in Stella's circus. Ash originally dressed as one to encourage the old Mr. Mime, soon confusing his mother when a wild Mr. Mime arrived at her house.
Another Mr. Mime appeared in It's Mr. Mime Time as one of the Pokémon in Stella's circus. However, it was lazy and stopped obeying her because she was too hard on it. It eventually listened to her once more when it saw how much she was willing to protect it from Team Rocket.
A Mr. Mime appeared in Stage Fight!, where it was part of a showboat stage show along with other Pokémon.
A Mr. Mime appeared in Hail to the Chef, under the ownership of Rhonda, a girl who lives outside Saffron City. She was competing with her sister Rhoda, who owned a Sneasel, for the ownership of her father's restaurant. Mr. Mime's cooking made the food taste horrible, but with help from Brock, its cooking improved.
Valerie owns a Mr. Mime in Quilladin Stands, where it was used to help stop the Ultimate weapon from activating. Bryony's familiarity with the tactic used by Valerie's Mr. Mime, by means of referring to pages from an encyclopedia, is a direct reference to the two occasions the tactic was previously used in Pokémon Adventures.
In all official artwork and in-game sprites prior to the release of Pokémon FireRed and LeafGreen, Mr. Mime only had four fingers. However, Mr. Mime has always had five fingers in the anime.
Mr. Mime appears to be based on a combination of a clown, a mime, and the pantomime of pretending to be trapped in invisible boxes. Its feet also appear to be reminiscent of the various hook-toed shoes worn by jesters. Its jerky animations and jaw suggest that it may also be a tsukumogami of a jointed puppet, dummy, or doll.
Mr. Mime is mime with an English male honorific. This gendered name was assigned before the gender mechanic was introduced in the games and is not reflected by the species' gender ratio.
Barrierd may be a combination of barrier (referring to the mime trait of 'being trapped' behind invisible walls) and weird or barricade.