Ash, Clemont and Bonnie first encountered Dedenne during their journey to Santalune City. Bonnie was eager to care for the cute Pokémon, and asked Clemont if he would catch it for her to allow her to raise and take with her when she was old enough to be a Pokémon trainer. Clemont agreed, and Ash helped her however Dedenne ran off scared when a Fletchling stole the food it was being offered.
Soon after, Dedenne reappeared to the group and stole some food and the gang gave chase. This resulted in Pikachu getting lost alongside Dedenne. The two became friends, and managed to save each other from Team Rocket. After this, Clemont captured Dedenne and then allowed it out of its Poké Ball so it could stay with Bonnie in her satchel.